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First, a large proportion of evidence still comes from preclinical animal studies, which, while informative, may not fully replicate human physiological complexity

10.3389/fimmu.2021.652252 Front Immunol

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Pregnancy and lactation safety has not been systematically studied, and as with most cosmetic and research compounds lacking definitive pregnancy safety data, conservative practice typically suggests avoiding use during pregnancy unless clearly needed, though the natural occurrence of GHK-Cu in the body and minimal systemic absorption from topical use suggest risk is likely to be low

They also nest occasionally on the ground in tall grass or amongst stones near water, or in cavity in bank or wall